Ccix. the Effect of Rise in Tempera- Ture on the Carbohydrate Catabolism of Cerebral Cortex

THE effect of rise in temperature on the respiration and glycolysis of animal tissues has been studied by Kubowitz [1929] and by Nakashima [1929]. Kubowitz using frog retina showed that aerobic glycolysis suddenly becomes apparent above 35°. The Pasteur effect is abolished above this temperature since the Meyerhof quotient descends to zero. Nakashima employed fish retina, which, like amphibian and unlike mammalian retina, shows little or no aerobic lactic acid production at normal temperatures. Nakashima found that in fish retina rise in temperature from 30 to 37.50 produces a large aerobic glycolysis, but here in contrast to frog's retina respiration is increased. The anaerobic glycolysis is also increased, but in spite of this Nakashima concluded that there is inhibition of the Pasteur effect embodying a fall in Meyerhof quotient at this high temperature. In the present communication the effects of abnormally high temperatures on the metabolism of cerebral cortex are described.